Heart Disease and Restless Legs (RLS)
John Winkelman, MD, PhD of the , Division of Sleep Medicine, Brigham & Women’s Hospital, Harvard Medical School, in Brighton, MA, and colleagues conducted a clinical study designed to examine the association between RLS and cardiovascular disease. Their sample for this evaluation was over 1,500 men and nearly 1,900 women with an average age of about 68 years.
Restless Legs (RLS) and Heart Disease Study
In this study, Restless Legs (RLS) was diagnosed by the subjects’ responses to a validated self-administered questionnaire. Coronary artery disease (CAD) was diagnosed based on the presence of angina, history of heart attack or angioplasty. Cardiovascular disease (CVD), by definition, included CAD history of stroke. The relationship between Restless Legs (RLS) and CVD was determined using validated statistical tools.
Of all of the subjects enrolled in the trial, it was determined that overall, Restless Legs (RLS) was present in about 7% of women and 3% of men. After the final statistical analysis, it was determined that the incidence of both CAD and CVD was twice as prevalent in patients suffering from the symptoms of Restless Legs (RLS) than those that were not afflicted. The associations tended to be even stronger in cases of patients who had Restless Legs (RLS) symptoms at least 16 times per month, and stronger yet in patients with the most severe Restless Legs (RLS) symptoms.
Based on these findings, Dr. Winkelman, and colleagues, concluded that Restless Legs (RLS) is associated with a greater prevalence of coronary artery and cardiovascular disease, with the highest association in patients with more frequent or severe symptoms (Neurology January 1, 2008 vol. 70 no. 1 35-42).
While this study does not determine if cardiovascular disease is causing Restless Legs (RLS), or vice versa, it does show a very strong correlation. Based on similar work showing the impact of sleep deprivation and resultant stress on human pathology, it makes sense to treat the symptoms of Restless Legs (RLS). Using CalmLegs™, a high quality formulation designed to provide for effective treatment of Restless Legs (RLS), with a benign safety profile, may be a good option for people with Restless Legs (RLS) in their attempt to get a good night’s sleep and avoid the consequences of the disorder.
Bradley Gillespie, PharmD
Health Expert, Restless Leg Sufferer
“I get a creepy-crawly feeling in my legs that makes me want to get up and move constantly, after 3 weeks of using Calm Legs I can finally relax and my life is so much better”