Should you use Drugs to treat Restless Legs?

Requip MiraPlex and Restless Legs (RLS)

Pros and Cons of Drug Therapy

In April of 2013, TJ Wilt, MD, of the Minneapolis Veterans Affairs Medical Center, in Minneapolis, MN, and investigators, published in the Journal of the American Medical Association (Internal Medicine), a review evaluating the pros and cons of treating Restless Legs (RLS) using conventional, FDA-approved drug products in the management of Restless Legs (RLS). In order to complete their work, they systematically gathered all available evidence from a total of 29 peer-reviewed medical journal articles, describing well-controlled clinical studies, of at least 4 weeks in duration.

The outcomes of interest were a clinically beneficial impact on the symptoms of Restless Legs (RLS) and related adverse events. As might be expected, in many cases the drugs worked, showing clinically important responses in patients receiving dopamine agonists (drugs like Requip [ropinirole] and Mirapex [pramipexole]). Further to that, evidence was found showing that other drugs, such as Neurontin (gabapentin) and Lyrica (pregablin) also were effective, compared to sugar pill.

Side Effects of Drugs used to treat Restless Legs (RLS)

As has been stated so many times in the past, nonetheless, there is no free lunch. In fact, in this article, the authors also reported adverse events to include nausea and vomiting in patients who received dopamine agonists. In the trials were patients received Lyrica or Neurontin, unsteadiness and dizziness were commonly reported.

The authors concluded by stating that based on their review of clinical studies, pharmacological interventions, can indeed alleviate some symptoms of Restless Legs (RLS) and improve sleep outcomes. Further to that, though, they also stated that adverse effects, and treatment withdrawals due to these adverse effects were common (JAMA Intern Med. 2013 Apr 8; 173(7):496-505).

The tolerance issues associated with the use of conventional pharmacological therapy are an eye opener, a startling finding, suggesting that the gentler Calm Legs™ approach to helping alleviate the symptoms of Restless Legs (RLS) may be a better choice for many individuals.

Bradley Gillespie, PharmD
Health Expert, Restless Leg Sufferer


man“I have been a police officer for many years and suffered with Restless Legs (RLS). My physician put me on a drug and told me at the time it was not addictive. He was wrong. Going through withdrawal has be unbearable and finding something to help has been difficult. I have been using your supplement for several weeks and am seeing some benefits. Most night I am getting some sleep. Although I still have some episodes of Restless Legs (RLS), they have been decreasing. Life is more manageable now.”                                   Roger, Ohio