Bradley Gillespie, PharmD ,Health Expert, Restless Leg Sufferer
If kidney failure was not bad enough, another unwanted consequence often observed in patients undergoing dialysis is Restless Legs (RLS). As in most other cases, Restless Legs (RLS) puts a damper on quality of life, often leading to insomnia and a resultant decreased quality of life.
Although the link between dialysis and Restless Legs (RLS) has not been fully worked out, it is well accepted that patients with renal impairment, undergoing dialysis often suffer high levels of oxidative stress. Oxidative stress has also been implicated in an increased incidence of Restless Legs (RLS). One logical approach, then, to treating the symptoms of Restless Legs (RLS) could be to try and lower the individual’s level of oxidative stress.
Restless Legs (RLS) Study
Mohammed Sagheb, of Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, in Shiraz, Iran, and colleagues, conducted a clinical study to characterize the impact of Vitamin C and E on the symptoms of Restless Legs (RLS) in dialysis patients. In this study, they enrolled a total of 60 dialysis patients who met the diagnostic criteria for Restless Legs (RLS). Patients were generally healthy, with no illnesses present.
The patients were divided into four groups of 15 patients, each, receiving either: Vitamin C and Vitamin E; Vitamin C; or a sugar pill. All patients were administered these treatments every day for 8 weeks. International Restless Legs (RLS) Scale (IRLS) scores were determined for each patient at baseline, as well as at the end of the treatment period. The outcome of interest was an absolute change in the IRLS score from baseline, to the end of the treatment phase.
At the end of the treatment phase, there was a significant decrease in the IRLS score, compared to baseline, in the patients treated with Vitamin C as well as in patients receiving Vitamins C & E. The authors concluded that Vitamin C, as well as the combination of Vitamins C & E, are safe and effective treatments for reducing the severity of RLS in dialysis patients (Sagheb, et al Sleep Med. 2012 May;13(5):542-5).
Calm Legs and Restless Legs (RLS)
Vitamin C may also be beneficial in Restless Legs (RLS) patients because it is known to also enhance the absorption of dietary iron diet. Because of this, both Vitamin C and E, are key ingredients in the patented CalmLegs® formulation.
“I have diabetes, am anemic and am on dialysis treatments. Sitting for hours is unbearable. I can now sit through my treatments without worry that the pain and discomfort I used to experience will come back.”